Search results for "zero-inflated negative binomial"

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Assessment of Susceptibility Risk Factors for ADHD in Imaging Genetic Studies

2019

Objective: ADHD consists of a count of symptoms that often presents heterogeneity due to overdispersion and excess of zeros. Statistical inference is usually based on a dichotomous outcome that is underpowered. The main goal of this study was to determine a suited probability distribution to analyze ADHD symptoms in Imaging Genetic studies. Method: We used two independent population samples of children to evaluate the consistency of the standard probability distributions based on count data for describing ADHD symptoms. Results: We showed that the zero-inflated negative binomial (ZINB) distribution provided the best power for modeling ADHD symptoms. ZINB reveals a genetic variant, rs273342…

MaleGenotypeImaging geneticsPopulationNegative binomial distributionPolymorphism Single NucleotideADHD symptomsImaging Genetics03 medical and health sciencesImaging Three-Dimensional0302 clinical medicineOverdispersionRisk FactorsStatisticsmental disordersDevelopmental and Educational PsychologyStatistical inferenceHumansGenetic Predisposition to Disease0501 psychology and cognitive sciencesGenetic TestingLongitudinal StudiesPoisson DistributionProspective Studiesp-valueMAPRE2Childeducationchildhoodzero-inflated negative binomialeducation.field_of_studyModels Statisticalbasal ganglia perivascular volumes05 social sciencesMagnetic Resonance Imagingcount dataVirchow-Robin spaceBinomial DistributionClinical PsychologyAttention Deficit Disorder with HyperactivityChild PreschoolProbability distributionFemalePsychology030217 neurology & neurosurgery050104 developmental & child psychologyCount data
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